How does age impact the success of IVF treatment, and what are the options for women over 40

The age does matter in the success of IVF treatment. When you are below the age 35 there are the greater chances that the IVF will be successful. With increase in your age, the success rate of your IVF treatments declines. The success rate of IVF is even lower for women greater than age 42.

Fertility After Age 40 – IVF in the 40s

Fertility after 40s

Fertility after the age of 40 typically declines significantly. Women experience a decrease in the quantity and quality of eggs, making conception more challenging. Diminished ovarian reserve becomes more prominent, reducing the chances of natural pregnancy without medical assistance. The risk of miscarriage also increases. It's important to note that fertility is a complex matter. While the chances of natural conception decline, some women may still become pregnant without medical intervention. 

IVF in the 40s

IVF (in vitro fertilization) can be a viable option for women in their 40s facing fertility challenges. While success rates generally decrease with age, IVF can still offer a chance of pregnancy. Women in their 40s may require a thorough fertility evaluation to assess ovarian reserve and hormone levels. Donor eggs from younger women may be considered to improve the chances of success.

If you are over the age of 40, there may be complications of pregnancy. It will be beneficial for you to work closely with a fertility specialist and discuss your condition. You should also explore options like preimplantation genetic testing (PGT), and receive personalized guidance throughout the IVF process.

How Does Egg Quality Affect Fertility and IVF?

Egg quality is really important when it comes to your fertility and IVF success. With increase in age, your egg quality decreases. That's why it is difficult to conceive after the 40s or a successful IVF treatment after the 40s. The poor quality of your egg can make it difficult to be fertilized with your partner’s sperm, which in turn makes it difficult for you to get pregnant.

Usually in IVF also, the health care providers choose the mature egg with high quality egg to increase the chances of successful IVF. Fertility specialists can evaluate your egg quality through tests and provide unique treatments based on your individual circumstances.

How Does Egg Quantity Affect Fertility and IVF Success Rates?

Egg quantity, also known as ovarian reserve, significantly affects fertility and IVF success rates. A larger quantity of eggs indicates a healthier ovarian reserve and increases the chances of natural conception. In IVF, the number of eggs retrieved during the stimulation phase directly affects the success rates of IVF. More the quantity of eggs, greater will be the chances of healthy embryos which also increases the chances of pregnancy. With increase in age, the ovarian reserve or egg quantity decreases which affect the fertility and IVF success rates.

This decline in egg quantity is associated with decreased fertility and lower IVF success rates, particularly in advanced maternal age. Assessing your ovarian reserve will be important for personalized treatment planning that enables your fertility specialists to optimize stimulation protocols and maximize the chances of your successful pregnancy.

In Vitro Fertilization Success Rate Statistics by Female Age – and After Age 40


Here are some approximate statistics regarding IVF success rates based on female age:

Female Age IVF Success Rate Statistics in India IVF Success Rate
Under 35 Year Old Birth Success Rate Per IVF Cycle 40-50%
Pregnancy Rate Per IVF Cycle 50-60%
35-37 Years Old Birth Success Rate Per IVF Cycle 30-40%
Pregnancy Rate Per IVF Cycle 50-60%
38-40 Years Old Birth Success Rate Per IVF Cycle 20-30%
Pregnancy Rate Per IVF Cycle 40-50%
41-42 Years Old Birth Success Rate Per IVF Cycle 10-20%
Pregnancy Rate Per IVF Cycle 30-40%
Over 42 Years Old Birth Success Rate Per IVF Cycle Below 5%
Pregnancy Rate Per IVF Cycle Below 20%

In Vitro Fertilization Success Statistics from the CDC for Age 40 and Over

The Centers for Disease Control and Prevention (CDC) provided important information on the success rates of assisted reproductive technology (ART), including IVF, for the age group of 40s and older. According to CDC:

Live Birth Rate: The live birth rate per IVF cycle for women aged 40-42 was approximately 10%. Pregnancy Rate: The pregnancy rate per IVF cycle for women aged 40-42 was approximately 16%.

Everything You Need to Know about IVF for Women over 40

If you are a woman above the age 40, then you should consult with your fertility specialist about the following important topics:

Age-related fertility decline: you should know about how your age will affect the fertility and the success of fertility treatments.

IVF process: ask as many questions as you want to know everything about the IVF process. It is important for you to know all the important details about IVF.

Initial evaluation: go for the fertility tests that can tell you about your condition and how it will be going to affect all the fertility treatments you are going for.

Ovarian reserve: your doctor should know about the quantity of the eggs that your ovary makes to tell you about the success rate of IVF.

IVF steps: ask about the whole procedure and steps of IVF which includes:

  • Ovarian stimulation
  • Egg retrieval
  • Fertilization and embryo development
  • Embryo transfer

Preimplantation genetic testing: PGT will be beneficial to know about any abnormality present in your DNA that can cause a genetic disease in your baby.

Success rates: Ask about the success rates of IVF treatment from your fertility specialist according to your age.

Emotional and financial implications: IVF can be emotionally and financially challenging. It is important for you to have realistic expectations about the treatment you get.

Age Doesn’t Have to Define Your Path to Parenthood

Your journey to parenthood is not solely determined by age. While age can present challenges, advancements in fertility treatments like IVF have provided opportunities for individuals and couples to pursue parenthood regardless of their age. 

With the guidance of fertility specialists, there are various options and strategies available to help overcome age-related fertility obstacles and fulfill the desire to become a parent.

It may be difficult for you to get pregnant after your 40s but it is not impossible. You should always have hope while going for fertility treatment including IVF.

Risks of Getting Pregnant in Your 40s – Is it Safe?

Pregnancy in your 40s carries risks including lower fertility, increased chances of abnormalities in babies, pregnancy complications, and presence of other health compromised conditions.  Close monitoring, care before and during pregnancy, and consultation with your healthcare professionals are essential to know about these risks and promote a safe pregnancy experience.

Bottom Line on Getting Pregnant After 40

If you're trying to have a baby after the age of 40, the most important thing to know is that it might be harder and there could be more risks. It's really important to talk to a doctor and learn about the options available to increase your chances of getting pregnant and having a healthy pregnancy.

Success Rate of IVF First Time in India

Initial attempts at IVF usually have a success rate of 40%, particularly among women under 35 years of age. However, as age progresses, the chances of success become low. Women over 40 years have less chances of success on the first attempt of IVF. Consequently, women may find it necessary to undergo multiple cycles of IVF to optimize their chances of success.

Highest Success Rate of IVF in India

Currently, the success rate for IVF in India ranges from 35% to 40% but it differs from patient to patient due to the unique cause of infertility. Generally, IVF technology have high rate of success and certain fertility specialists in India achieve an impressive IVF success rate of 80% to 90%. This higher success rate is due to the availability of advanced technology and the application of skilled techniques by the fertility specialists.

FAQs of The Success of IVF Treatment

How successful is IVF for women over 40?

The success rate depends on the egg maturity and quantity. After age 40, the egg quality starts declining which lowers the chances of successful IVF to 10%.

What is the best IVF protocol for over 40?

Close monitoring, prenatal care, and consultation with your healthcare professionals and thorough check ups will be the best IVF protocol for women over age 40.

Which IVF method is better for older women?

There is no specific method of IVF for older women but the chances can be increased by focusing on the general health of women. 

How successful is IVF on the first try?

There are 40-50% chances of successful IVF on the first try when a woman is under the age 35.

Which stage of IVF is most difficult?

There can be a slight discomfort at the stage where the egg is retrieved from the woman’s body. It usually performs under the effect of anesthesia for reducing pain and irritation.

How can I increase my IVF success rate?

To increase IVF success rate, improve overall health, manage the stress levels and follow a healthy lifestyle.

What is a better option than IVF?

There isn't a universally better option than IVF but alternatives like surrogacy, or adoption may be considered.

How old is too late for IVF?

There is no strict age limit for IVF, but success rates decline with age, and the chances of conceiving decrease significantly after 40.

Is IVF better than IUI for over 40?

IVF may offer higher success rates as compared to IUI for women over 40.

Should I go for IVF at 40?

Whether to go for IVF at 40 depends on individual factors and fertility evaluation. Consult with your fertility specialist and make an informed decision based on your specific condition.